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Methylation of the CpG islands in the NRF2 gene promoter typically suppresses NRF2 transcriptional activity, leading to reduced expression levels and impacting the cells antioxidant functions [148]
526 Clinical trials testing various doses of SYL1801 eye drops in healthy volunteers showed good safety and tolerability
45 The results demonstrated an improvement in health-related quality of life, decreased respiratory exacerbations, fewer hospital days and a reduced cost of health care in the active drug group
doi: 10.1016/j.addr.2012.01.020
