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This approach is justified by the study of Vickery and Hamlin(101), who found, on both clinical and pathologic grounds, that the disease may remain static and the clinical condition unchanged over many years

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Based on tracing studies in rhesus macaques (Figure 1A), area 25 is densely connected with neighboring ventromedial and posterior orbitofrontal cortex (OFC), involved in affective evaluation and a moderate pathway linking it to fronto-polar area 10 and cognition

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