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The free cholesterol is esterified by the enzyme lecithin-cholesterol acyltransferase (LCAT), which is present in nascent HDL and activated by its cofactor, apo A-I

Within the body, it is located mostly in the skeletal and cardiac muscle tissue, liver, kidney, brain, and reproductive organs--all areas of high physiological activity

In addition, small non-coding RNAs have been found to impact atherosclerosis development by regulating inflammation and/or cholesterol homeostasis in different cell types in lesions (76,77)

In particular, the PI3K/Akt signaling pathway was closely related to various enzymatic activities in glucose metabolism to enhance glycolysis and to provide energy for the body during exercise (Xie et al., 2019)

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