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Description
Oncotarget 9(11):9714-9727, 2018

Osmo-inelastic response of the intervertebral disc

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Apart from the GSH-GPX4 inhibitory pathway, which is recognized as the predominant ferroptosis regulatory system (31), one such mechanism involves ferroptosis suppressor protein 1 (FSP1, also known as AIFM2), which inhibits lipid peroxidation and ferroptosis by synthesizing panthenol and rejuvenating oxidized -tocopherol radicals (vitamin E) (32,33)

Originally isolated from a protein found in human gastric juice
