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Description
Mutant isocitrate dehydrogenase 1/2 (IDH1/2) produces the oncometabolite 2-hydroxyglutarate (2-HG), which inhibits -KGdependent dioxygenases, resulting in widespread epigenetic dysregulation [98-100]
GSVA was performed as implemented in the GSVA R package version 1.26 on the basis of the cluster-averaged log-transformed expression matrix
Similar to the process of light capture in the outer segment, the propagation of the visual signal through subsequent neurons is very energetically costly [[81], [82], [83]] and is highly susceptible to oxidative damage [84,85]
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10.1007/s11064-020-03173-1 Neurochem Res
