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Keywords: IGF-1, Laron syndrome, Hypophysectomy, Hypotrichosis, Androgenetic alopecia, Growth hormone deficiency Established Facts Insulin-like growth factor 1 (IGF-1) has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology
