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6 Gut microbiota dysbiosis and cytokine abnormalities 6.1 Evidence for the association between cytokines and schizophrenia Given the dysfunction of the BBB in patients with schizophrenia, changes in cytokine levels in the periphery (peripheral blood) and the center (cerebrospinal fluid, CSF) are valuable for assessing the CNS inflammatory state

Thus, folate deficiency induces GNMT activity, whereas choline and methionine deficiency inhibits it (Figure 3)