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Nature 447, 425432
Hydrolysis occurs when water molecules attack peptide bonds, literally breaking the amino acid chain apart
At the same time, while DFMO shows promise in animal models, it has failed in a single-subject case study 550 and causes side effects during long-term administration, prompting the need for better therapeutics
Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis
This is why working with a trained provider who understands medicine is important
