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In the gastrointestinal tract, tryptophan metabolism proceeds through three main pathways: (1) direct microbial conversion of tryptophan to various aryl hydrocarbon receptor (AhR) ligand molecules, such as indole-3-acetic acid (IAA), indole-3-aldehyde, and indole-3-propionic acid

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Furthermore, in high-grade serous ovarian cancer (HGSC), high CSF1 mRNA levels correlate with a dense infiltration of CD163+ TAMs, as evidenced by Nanostring gene expression analysis and immunohistochemical staining

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