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Interestingly, researchers have shown that PC is highly expressed in early NSCLC cells, and knockdown of PC leads to reduced cell growth and proliferation and lower TCA cycle activity due to the reduction of compensatory intermediates, resulting in the reduction of lipid and nucleotide synthesis and the imbalance of GSH, which may lead to the excessive production of ROS (62)

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[DOI] [PubMed] [Google Scholar] Alcain FJ, Villalba JM

c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2

Kaldur T, Unt E, pik V et al (2016) The acute effects of passive heat exposure on arterial stiffness, oxidative stress, and inflammation
