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Furthermore, structural analysis of IDPs/IDRs that rapidly fluctuate between a wide range of conformations in a dynamic ensemble, rather than settling into a single, rigid structure cannot be conducted by X-ray crystallography, which, for an ordered protein, produces a single time- and space-averaged model

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WH: Writing original draft, Data curation, Methodology

Proteome instability is an immunogenic therapeutic vulnerability in mismatch repair deficient cancer

Dual localization of the gene product in these two compartments has also been demonstrated in Arabidopsis (Chew et al., 2003)