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36 However, this should not be taken to mean that vedolizumab is superior to all anti-TNFs

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H (2017) Loss of homeostatic microglia and patterns of their activation in active multiple sclerosis

The content of melanin in melanocytes was increased by maclurin in a dose-dependent manner, by a mechanism involving the activation of the cAMP/PKA/CREB signaling pathway, which in turn increased tyrosinase, MITF and their downstream TRP-1 and Trp-2 protein content, while also involving the activation of p38 MAPK and p44/42 MAPK pathways