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The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production

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Supplementary Figure S5 shows the hydrogen bonds formed between each component and key targets and the binding sites of amino acid residues

Consistent with these observations, a major reduction in intracellular glutathione levels was observed in PBMC lysates from COVID-19 patients compared to HCs ( Figure 4I ), suggesting an impaired intracellular host antioxidant response to control oxidative stress responses and ultimately lipid peroxidation

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