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NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation

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Idasanutlin has been evaluated in preclinical studies for the treatment of AML and has shown promising results, particularly in combination with cytarabine

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These target genes were annotated in 47 signaling pathways, including Wnt signaling pathway, Hippo signaling pathway, ferroptosis pathway, and mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that ferroptosis may serve as a potential novel target for AIH therapy [248]