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Acknowledgements This research was supported by the South Carolina Clinical & Translational Research Institute, with an academic home at the Medical University of South Carolina, CTSA NIH/NCATS grant numbers UL1TR001450 and UL1TR000062, NIH F31NS108623, and NIDA DA003906

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doi: 10.1186/s13229-021-00447-5 151 Zuiderwijk-SickE

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While small molecular inhibitors remain in high demand due to their moderate adverse effects, further efforts are needed to enhance treatment response
