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Br J Cancer

These evidences suggest that serum androgens and AR protein levels in metabolic tissues are non-negligible factors in deciphering the mechanism behind sexual dimorphism in metabolic health, and in establishing a precise sex-based therapeutic strategy for the prevention and treatment of metabolic diseases

While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

Pain 17 ChuiH.GerstorfD.HoppmannC

Besides, TMAO is excreted mainly through the kidney, 96% of which is eliminated in urine by 24 h (Taesuwan et al., 2017)