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[53] showed that topical application of dexpanthenol cream showed no significant wound reduction compared to N -acetyl cysteine

12 The pathology then continues to propagate rostrally to more central structures, such as the substantia nigra, leading to the emergence of motor symptoms

See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Co., 17th Ed

Nevertheless, in mitochondrial dysfunctions that affect the early stages of brain embryonic development or perinatal stages, maturity may not become a barrier