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238 Inhibiting the demethylase activity of FTO with Rhein can sensitize resistant cells to TKIs, downregulate Bcl-2 and MER proto-oncogene, tyrosine kinase (MERTK), thus regulating the PI3K-AKT-mTOR pathway and the Bcl-2 family of proteins, which affects the invasion and apoptosis of cancer cells
Bolick DT, Skaflen MD, Johnson LE, Kwon SC, Howatt D, Daugherty A, Ravichandran KS, Hedrick CC
Lee J, Hudson MR, OBrien TJ, Nithianantharajah J, Jones NC
[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Demarquoy J
Double-blind trial in duodenal and gastric ulcers
