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90 PHARMACOLGIC ACTIVATION OF MELANOCORTIN1 RECEPTOR Approved Melanocortin pharmacotherapies In addition to conditions and environmental factors that promote physiologic MC1R activation, there are also MC1R agonists and various other pharmacologic treatments that activate MC1R signalling that are commercially available and in development in the United States and/or European Union for indications including erythropoietic protoporphyria (EPP), sexual desire disorders and monogenic and syndromic obesity (Table 2, 60 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 )

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